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Post-doctoral fellow Milan Company: San Raffaele - Telethon Institute for Gene Therapy Department of Microglia development Start in 01 April 2018 Duration: 3 years

Postdoctoral Fellowship

Human development and disease modeling Lab - Andrea Ditadi

One post-doctoral position is available in the laboratory of Dr. Andrea Ditadi at the SR-TIGET in Milan. Our lab combines developmental cell and molecular biology to understand normal and pathological human hematopoietic development, with a particular interest in studying the genetic origins for blood disorders and developing novel strategies for their treatment.

The successful candidate will be in the unique position to integrate stem cell biology, immunology and neuroscience to study human microglia development and functions at the molecular and genetic level using hESCs/hiPSCs and mouse models. This ambitious project entails the use of CRISPR-Cas9 genome editing, in vitro and in vivo assays and genomics. The position is open for a proactive self-motivated postdoctoral fellow, holding a PhD degree in molecular and cell biology, biochemistry or relevant field for no more than 4 years. The ideal candidate should have a strong background in immunology and/or neuroscience, cell biology and molecular biology, flow cytometry and have documented research experience in competitive labs, excellent communication and multi-tasking skills, and be team-oriented. Proficiency in in oral and written English is a must, while competence in bioinformatics and epigenetics is a significant asset but not required. The position can start on April 1st at the earliest and is available for three years.

Milan is a vibrant international city and is an excellent location for arts, commerce, design, entertainment, fashion and gastronomy. The host institution (Ospedale San Raffaele) is one of the leading research institutes in Italy. We offer excellent working conditions, including a highly competitive salary, state-of-the-art facilities and infrastructures (Next-Generation Sequencing, Cell Sorting and Imaging, Animal Facilities, GLP laboratories), and direct access to clinically relevant human samples. SR-TIGET is a world-leading Institute in the areas of gene and cell therapy for the treatment of human genetic diseases; thus, our projects benefit from close collaborations with active clinicians and are expected to accelerate the development of techniques that could be translated to the clinic.

Informal enquiries and applications can be sent to Dr. Andrea Ditadi (ditadi.andrea@hsr.it) describing briefly career goals and including CV and contact information for 2-3 references.

PhD Student Genova Company: Istituto Italiano di Tecnologia Department of Center for Synaptic Neuroscience and Technology Start in 01 November 2018 Duration: 3 years

One doctoral position in "NEUROTROPHIN SIGNALING AND NEUROINFLAMMATION"

A three-year doctoral position is available in Dr. Benfenati’s group, at the IIT Centre for Synaptic Neuroscience (Genova, Italy). The focus of the research project will be the analysis of the cellular and molecular mechanisms mediating neurotrophin signaling in the adult brain, by using transgenic mouse lines that are defective in neurotrophin signaling. The phenotypic analysis of mutant animals will be conducted through biochemical, cell biology, histological and behavioral techniques. Following a parallel and complementary approach, we will also study the molecular mechanisms of neuroinflammation, by focusing on the alteration of trophic signals and of gene transcription in in vitro/in vivo models of inflammation. The successful candidate will hold a Master degree in Biosciences (Medicine, Biology, Pharmacy, Biotechnology and similar) and have a good background in cellular and molecular neurobiology. Some experience in working with transgenic animals will be an advantage.

The research activity will be carried out at the Fondazione Istituto Italiano di Tecnologia (IIT), a Foundation created with the objective of promoting Italy's technological development and higher education in science and technology. Research at IIT is carried out in highly innovative scientific fields with state-of-the-art technology. Within IIT, the Centre for Synaptic Neuroscience and Technology is located at the IRCCS San Martino Hospital/University of Genova, it hosts scientists with strong multidisciplinary expertise and provides state-of-the-art laboratory facilities.

Starting date: Nov 1st, 2018. The call will close on May 31st, 2018.

To apply please send CV, research interest statement and names of at least 2 referees to Dr. Fabrizia Cesca (fabrizia.cesca@iit.it) and Dr. Fabio Benfenati (fabio.benfenati@iit.it) by Apr 30th, 2018.

PhD student Genova Company: Istituto Italiano di Tecnologia Department of Center for Synaptic Neuroscience and Technology Start in 01 November 2018 Duration: 3 years

One doctoral position in "MODULATION OF BLOOD-BRAIN BARRIER PERMEABILITY"

A three-year doctoral position is available in Dr. Benfenati’s group, at the IIT Centre for Synaptic Neuroscience (Genova, Italy). The research project will study the molecular and cellular mechanisms controlling the transcellular and paracellular permeability of the blood-brain barrier (BBB). With the support of structural and computational studies, and by eventually engineering optogenetic probes, this study aims at finding peptides or small molecules able to transiently and reversibly open the BBB. This approach will be applied to: (i) devise new drug delivery strategies for treating central nervous system (CNS) diseases; and (ii) rescue BBB functionality in genetic CNS disorders in which important components of the barrier are mutated. The successful candidate will hold a Master degree in Biosciences (Medicine, Biology, Pharmacy, Biotechnology and similar) and have a good background in cellular and molecular neurobiology. Previous experience with patch-clamp electrophysiology and in vitro/in vivo BBB models will be an advantage.

The research activity will be carried out at the Fondazione Istituto Italiano di Tecnologia (IIT), a Foundation created with the objective of promoting Italy's technological development and higher education in science and technology. Research at IIT is carried out in innovative scientific fields with state-of-the-art technology. Within IIT, the Centre for Synaptic Neuroscience and Technology is located at the IRCCS San Martino Hospital/University of Genova, it hosts scientists with strong multidisciplinary expertise and provides state-of-the-art laboratory facilities.

Starting date: Nov 1st, 2018. The call will close on May 31st, 2018.

To apply please send CV, research interest statement and names of at least 2 referees to Dr. Fabio Benfenati (fabio.benfenati@iit.it) and Dr. Fabrizia Cesca (fabrizia.cesca@iit.it) by Apr 30th, 2018.

PhD Student Genova Company: Istituto Italiano di Tecnologia Department of Center for Synaptic Neuroscience and Technology Start in 01 November 2018 Duration: 3 years

One doctoral position in "EPIGENETICS IN THE ADULT BRAIN"

A three-year doctoral position is available in Dr. Benfenati’s group, at the IIT Centre for Synaptic Neuroscience (Genova, Italy). The project will study the role of RE1-silencing transcription factor (REST) in maintaining adult brain plasticity. REST is an inhibitory transcription factor that plays a fundamental role in several neurophysiological processes, and which is altered in a number of neurological disorders, including epilepsy. The research will be conducted at two levels. In vitro studies will be performed to analyze the molecular mechanisms mediating REST activity under normal conditions as well as upon induction of hyperexcitability. The in vitro findings will be complemented by an in vivo approach, by using transgenic mouse lines that lack REST specifically in excitatory and inhibitory neurons. The phenotypic analysis of mutant animals will be conducted through biochemical, molecular, immunochemical and behavioral techniques. The successful candidate will hold a Master degree in Biosciences (Medicine, Biology, Pharmacy, Biotechnology and similar) and have a good background in cellular and molecular neurobiology. Experience in molecular cloning and/ or in working with transgenic animals will be an advantage.

The research activity will be carried out at the Fondazione Istituto Italiano di Tecnologia (IIT). Research at IIT is carried out in innovative scientific fields with state-of-the-art technology. Within IIT, the Centre for Synaptic Neuroscience and Technology is located at the IRCCS San Martino Hospital/University of Genova, it hosts scientists with multidisciplinary expertise and provides state-of-the-art laboratory facilities.

Starting date: Nov 1st, 2018. The call will close on May 31st, 2018.

To apply please send CV, research interest statement and names of at least 2 referees to Dr. Fabio Benfenati (fabio.benfenati@iit.it) and Dr. Fabrizia Cesca (fabrizia.cesca@iit.it) by Apr 30, 2018.

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