Job offers

Post-doctoral fellow Milan Company: San Raffaele - Telethon Institute for Gene Therapy Department of Microglia development Start in 01 April 2018 Duration: 3 years

Postdoctoral Fellowship

Human development and disease modeling Lab - Andrea Ditadi

One post-doctoral position is available in the laboratory of Dr. Andrea Ditadi at the SR-TIGET in Milan. Our lab combines developmental cell and molecular biology to understand normal and pathological human hematopoietic development, with a particular interest in studying the genetic origins for blood disorders and developing novel strategies for their treatment.

The successful candidate will be in the unique position to integrate stem cell biology, immunology and neuroscience to study human microglia development and functions at the molecular and genetic level using hESCs/hiPSCs and mouse models. This ambitious project entails the use of CRISPR-Cas9 genome editing, in vitro and in vivo assays and genomics. The position is open for a proactive self-motivated postdoctoral fellow, holding a PhD degree in molecular and cell biology, biochemistry or relevant field for no more than 4 years. The ideal candidate should have a strong background in immunology and/or neuroscience, cell biology and molecular biology, flow cytometry and have documented research experience in competitive labs, excellent communication and multi-tasking skills, and be team-oriented. Proficiency in in oral and written English is a must, while competence in bioinformatics and epigenetics is a significant asset but not required. The position can start on April 1st at the earliest and is available for three years.

Milan is a vibrant international city and is an excellent location for arts, commerce, design, entertainment, fashion and gastronomy. The host institution (Ospedale San Raffaele) is one of the leading research institutes in Italy. We offer excellent working conditions, including a highly competitive salary, state-of-the-art facilities and infrastructures (Next-Generation Sequencing, Cell Sorting and Imaging, Animal Facilities, GLP laboratories), and direct access to clinically relevant human samples. SR-TIGET is a world-leading Institute in the areas of gene and cell therapy for the treatment of human genetic diseases; thus, our projects benefit from close collaborations with active clinicians and are expected to accelerate the development of techniques that could be translated to the clinic.

Informal enquiries and applications can be sent to Dr. Andrea Ditadi (ditadi.andrea@hsr.it) describing briefly career goals and including CV and contact information for 2-3 references.

Postdoctoral Research Fellow Position Padova Company: University of Padova Department of Department of Biology Start in 01 January 2019 Duration: 12 months with possibility of extension

Postdoctoral Research Fellow Position @ Molecular Physiology and Biophysics Laboratory
Department of Biology, University of Padova

The laboratory of Molecular Physiology and Biophysics is seeking a highly motivated postdoctoral candidate to study the molecular mechanisms of neurodegeneration in Parkinson’s disease (PD). PD is an incurable neurodegenerative disorder affecting more than 5 millions of people worldwide. PD is characterized by i) dopaminergic neuronal death, ii) the presence of proteinaceous accumulations positive for alpha-synuclein (a-syn) in the surviving neurons as well as in astrocytes and, iii) extended gliosis and neuroinflammation. The majority of the research on PD has focused on neurons, but the contribution of non-neuronal cells to the neuropathology of this disease is nearly unexplored. Of note, astrocytes contribute to the maintenance of the health and function of the central nervous system. Thus, it is not surprising that these multifunctional cells might be implicated in the onset and progression of PD.
Causative mutations in different genes have been identified, allowing to model the molecular mechanisms of PD in genetic model organisms. Many of these genes function within the endo-lysosomal pathway and are highly expressed in astrocytes (e.g. LRRK2, GBA, ATP13A2) but their role in the astrocyte (patho)biology is totally unexplored.

Job description

Astrocytes are phagocytic cells and engulf axonal organelles as well as synaptic elements during development and in the adult. Astrocytes effectively degrade cell debris and protein aggregates via the lysosomal pathway. As a consequence, lysosomal impairment in these cells can interfere with astrocyte function and contribute to the onset and the disease progression of neurological disorders. Our aim is to establish how lysosomal dysfunction in astrocytes impacts on astrocyte biology and how this links to PD.
The candidate will i) investigate the impact of PD-linked proteins on lysosomal functionality in astrocytes, ii) unveil their role in a-syn degradation by astroglia and, iii) analyse the effect of undegraded a-syn in astrocytes on neuronal survival and outgrowth. Experimental approaches include biochemical, cellular and state-of-the-art imaging techniques in PD mouse models (e.g. LRRK2 loss- and gain- of function mice; tissue specific ATP13A2 loss- of function mice). We are surrounded by a large and multidisciplinary neuroscience community with a strong interest on neurodegeneration and actively collaborate with national and international research groups.

Candidate’s profile:

- Should have a PhD in the fields of Neuroscience, Biological Sciences or related fields
- Demonstrated records of achievements and publications
- Excellent communication skills, ability to work in a team / collaborative environment
- Ability to perform independent research and encouraged to develop his/her own research ideas
- Experience with animal work are welcome

The contract will last 12 months with possibility of extension. Motivated candidates should send a CV, a letter outlining interest/motivations and names/contact information of two references via email to:

Laura Civiero, PhD
laura.civiero@unipd.it

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