Novel Pharmacological Approaches in Migraine Therapy

This event is under the Patronage of the Italian Society for Neuroscience

Meeting Rationale

Migraine is among the most disabling forms of primary headache, endowed with a serious social impact and ranking as one of the top causes of years lived with disability worldwide, particularly in people under fifty. It is characterized by recurrent attacks of moderate to severe throbbing and pulsating pain on one side of the head and untreated attacks last from four to 72 hours. Pain is caused by the activation of nerve fibers within the wall of brain blood vessels traveling inside the meninges. Other common symptoms include increased sensitivity to light, noise, and odors, nausea, vomiting. Clustered populations suffering from the disease leave open the role of endogenous as well as exogenous triggers helping the definition of diverse pathophysiological paradigms for the exercise of research. Indeed, in the past, this clinical field has been characterized by poor knowledge on the pathophysiology of the disease leading to preventive approaches borrowed from drugs originally developed for other therapeutic indications, with consequent limited efficacy and endowed with unacceptable level of side effects causing scarce adherence. At variance with this situation, more than 35 years of pharmacological research effort have established a strong rational basis upon which the actually available disease modifying drugs have been developed. In fact, systematic investigations on calcitonin gene–related peptide (CGRP) have established its fundamental role in the pathophysiology of migraine through nociceptive mechanisms in the trigeminovascular system. The role of CGRP in migraine can be now considered clearly demonstrated also at the level of clinical trials of small-molecule CGRP-receptor antagonists in acute migraine and it is further supported in trials of biotech drugs including onabotulinum toxin A and monoclonal antibodies targeting the CGRP pathway in episodic and chronic migraine. Whilst all this will have a great impact on the frequency and management of acute manifestations as well as the whole history of chronic migraine, new and old questions remain to be answered. In this new scenario, in fact, several pathophysiological as well as therapeutic and regulatory questions remain open. The organizers of this meeting intended to contribute by calling basic and clinical scientists, among the most knowledgeable at the national and international level, as well as national and regional regulators to provide postgraduate students, young researchers and clinicians with their most up to date view on these matters.

Presidents

Giacinto Bagetta (Rende, Cosenza), Maria Tiziana Corasaniti (Catanzaro), Giovambattista De Sarro (Catanzaro)

Organizing Committee

Antonio Leo (Catanzaro), Damiana Scuteri (Catanzaro)

International Advisory Board

Annagrazia Adornetto (Rende), Diana Amantea (Rende), Salvatore Amoroso (Ancona), Fabio Blandini (Milan), Giovambattista Bonanno (Genoa), Luigi Brunetti (Chieti), Rita Citraro (Catanzaro), Domenico Conforti (Rende, Cosenza), Gianfranco Di Renzo (Naples), Ernesto Fedele (Genoa), Edoardo Ferlazzo (Catanzaro), Carmela Fimognari (Bologna), Luca Gallelli (Catanzaro), Kengo Hamamura (Fukuoka), Gary Lawrence (Dublin), Sabatino Maione (Naples), Hirocazu Mizoguchi (Sendai), Luigi A. Morrone (Rende), Domenico Pellegrini Giampietro (Florence), Pierluigi Nicotera (Bonn), Anna Maria Pittaluga (Genoa), Laura Rombolà (Cosenza), Rossella Russo (Cosenza), Giorgio Sandrini (Pavia), Shinobu Sakurada (Sendai), Antonella Scorziello (Naples), Paolo Tonin (Venice), Maurizio Taglialatela (Naples), Tsukasa Sakurada (Fukuoka), Antonio Siniscalchi (Cosenza), Marilù Vulnera (Cosenza)

Keynote Speakers & Chairs

Gennarina Arabia (Catanzaro), Oliver J Dolly (Dublin), Philip R Holland (London), Antonio Leo (Catanzaro), Sabatino Maione (Naples), Paolo Martelletti (Rome), Dimos Mitsikostas (Athens), Pierluigi Nicotera (Bonn), Giuseppe Pignataro (Naples), Damiana Scuteri (Catanzaro), Cristina Tassorelli (Pavia)

Invited Speakers & Chairs

Lucio Annunziato (Naples), Renato Bernardini (Catania), Fabio Blandini (Pavia), Francesca Bosco (Catanzaro), Annalisa Capuano (Naples), Stefania Ceruti (Milan), Alberto Chiarugi (Florence), Domenico Conforti (Rende, Cosenza), Giangennaro Coppola (Salerno), Giovambattista De Sarro (Catanzaro), Marina De Tommaso (Bari), Monica Di Luca (Milan), Edoardo Ferlazzo (Catanzaro), Pierangelo Geppetti (Florence), Rosario Iannacchero (Catanzaro), Gary Lawrence (Dublin), Antonio Leo (Catanzaro), Livio Luongo (Naples), Rossella E Nappi (Pavia), Francesca Operto (Catanzaro), Angelo Pascarella (Catanzaro), Patrizia Popoli (Rome), Giorgio Racagni (Milan), Simona Sacco (L’Aquila), Paola Sacerdote (Milan), Rita Scarpelli (Catanzaro), Damiana Scuteri (Catanzaro)

General Information

Registration fee: A registration fee of 250 € is to be paid beforehand via bank transfer (IBAN: IT35W0200880884000103544669) to: Department of Pharmacy, Health Sciences and Nutrition, University of Calabria, 87036 Rende, Cosenza, Italy (causal: registration fee meeting “Novel Pharmacological Approaches in Migraine Therapy”). The fee will allow to attend the meeting sessions. To limit the environmental impact of the meeting, the program will be available online by means of a QR code to be used with the smartphone. Meeting content and format The meeting is organized in basic, translational, clinical and regulatory sessions on head pain. Each session is preceded by a keynote speech of 30 minutes duration including discussion. The sessions include oral presentations of 20 minutes duration including discussion. The poster session will be Thursday 20th September. Posters will be discussed at lunch break, but they will be on display for all the duration of the meeting.

Accommodation: Accommodation for participants will be at an agreed discount rate at four stars Hotels in Rende (Cosenza). Transportation to/from the University will be available free of charge for registered participants from the Hotels. For further information, please, address the correspondence to the executive secretariat.

Language: The language of the meeting will be English, no translation will be available.

Social Program: Thursday, September 19th, 2024 the welcome dinner will be served at 20.30 at the Fellini Restaurant followed by Ethnic music and dance concert directed by M° Checco Pallone Friday, September 20th, 2024 the farewell dinner will be served at Villa Rendano (Cosenza) at 20.30 followed by Jazz music concert directed by M° Giuseppe Cosentino

Executive Secretariat: Dott. Giuseppe Oliva Department of Pharmacy, Health Sciences and Nutrition, University of Calabria, 87036 Rende, Cosenza, Italy; giuseppe.oliva@unical.it

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Compete for SINS Awards

We are pleased to announce the opportunity to compete for four awards of €250 each for the best posters presented by young SINS members at the “Novel Pharmacological Approaches in Migraine Therapy” conference, which will take place in Rende (Cosenza) on September 19-20, 2024.

Award Guidelines:

Eligibility: All young SINS members in good standing for the year 2024 who present a poster at the conference are eligible.

Poster Topics: Posters should present original and unpublished research in one of the following areas:

• Basic research on migraine or neuropathic pain (the latter only for basic research, given the limited number of migraine models available)
• Translational and clinical research on migraine.

Evaluation and Selection Committee: Posters will be evaluated by a committee of three members selected from colleagues participating in the meeting as speakers or chairpersons. The evaluation will be based on the originality and innovativeness of the research presented.

Poster Presentation and Discussion: Posters will be presented and discussed as outlined in the program, during the lunch break on September 20th.

Award Presentation: The awards will be announced before the conclusion of the meeting, based on the committee’s decision.

This is a great opportunity for you to showcase your innovative research and receive recognition from the scientific community.

For all further information, please contact the Executive Secretariat: Dr. Giuseppe Oliva, Department of Pharmacy, Health Sciences and Nutrition, University of Calabria; giuseppe.oliva@unical.it.