Description: We are looking for an excellent candidate to join our Adult Neurogenesis team. The project explores the role of the transcriptional regulator Nr2f1 within neural stem/progenitor cells and neurons focusing on the dentate gyrus of the hippocampus in adult mice. Mutations in NR2F1 coding sequence cause Boonstra-Bosch-Schaff optic atrophy syndrome (BBSOAS), a rare human autosomal-dominant neurodevelopmental disorder, which is characterized by multiple clinical features, including optic nerve atrophy, intellectual disability and autistic traits. Our recent data (Bonzano et al., DOI: 10.1242/dmm.049854) point to an active role for NR2F1 in the mitochondrial gene expression regulatory network in neurons and support the involvement of mitochondrial dysfunction in BBSOAS. In this project, by using different genetic mouse models of the disease, we aim to demonstrate the impact of mitochondrial dysfunction in the pathophysiology of BBSOAS.
The position is funded by the PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2022 – “Nr2f1-dependent regulation of Mitochondrial Function in Neural Development and Disease”. The gross salary is € 19.456/year.
Feel free to contact Silvia De Marchis (email@example.com) for further information.
Employer: Neuroscience Institute Cavalieri Ottolenghi (University of Torino)
Duration: 1 year assegno di ricerca
Application deadline: 20240122