Description: The project aims to investigate i) the mechanisms of initiation and propagation of cortical spreading depression (CSD) in wild-type mice and the mechanisms of its facilitation in genetic mouse models of migraine; ii) the mechanisms of facilitation of CSD by sleep deprivation, a known migraine trigger. Patch-clamp recordings combined with intrinsic optic signal imaging, glutamate imaging and pharmacology in acute cerebral cortex slices, as well as glutamate imaging in awake mice will be used. Expertise in neurophysiology and/or in patch-clamp recordings in brain slices or cultured cells is a mandatory prerequisite. The position and the salary will be commensurate with qualifications. Starting date: January 2024.

Employer: Dept of Biomedical Sciences, University of Padova

Location: Padova, Italy

Duration: 12-18 months pre/postdoctoral position

Application deadline: 20231231

How to apply: Submit your CV, a cover letter highlighting your expertise and motivations and contact details of two or three professional references to Daniela Pietrobon at daniela.pietrobon@unipd.it

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