Description: Cancer patients life expectancy is substantially increased. CNS neurotoxicity, defined as chemotherapy-induced cognitive impairment (CICI) is frequent, impairing memory, learning, etc during and after discontinuation of chemotherapy. Chemotherapy-induced PNS toxicity (CIPN) ranks among the commonest dose-limiting toxicities of several widely used anticancer drugs. The cellular and molecular events underlying CICI and CIPN pathogenesis still remain elusive. This project is based on 3 main pillars: 1: CICI and CIPN can be reliably modeled in new preclinical models based on schedules that are more close to the clinical use 2: CICI and CIPN may have detectable morphological and functional correlates 3: CICI and CIPN can be simultaneously modulated by the administration of histone deacetylase inhibitors.
We are looking for young motivated graduated students or post-docs with a degree in Biology, Biotechnology, Medicine and Surgery, Pharmacy, Medical Engineering or related disciplines interested in basic research.
Suggested skills: experience in animal experimentation, histology, immunocytochemistry, molecular analysis and confocal microscopy.
The salary will be €19.456€ (gross amount after deduction of the taxes of the employer). For additional benefits contact the PIs.
Please, if interested, contact the tutor for an interview.
Ref: Prof. Alessandro VERCELLI (firstname.lastname@example.org)
Employer: Neuroscience Institute Cavalieri Ottolenghi (University of Torino)
Duration: Two one-year position
Application deadline: 20240122