Start date: 20250127

End date: 20250127

Location: Palazzo Greppi, Milan

We are pleased to announce a series of workshops titled Dialogues on Brain Health, organized by the Italian Society for Neuroscience, featuring both national and international experts in the field of brain health. These events offer a unique opportunity to delve into pressing topics, share cutting-edge knowledge, and discuss the latest discoveries in Neuroscience. They represent a significant opportunity for learning and exchange, aimed at promoting greater awareness and innovation in mental and cognitive health.

This inaugural workshop, titled “The neuroscience of cognitive and behavioural flexibility: from function to dysfunction” focuses on the ability to adapt our behavior in response to changing or unexpected situations—a capacity that allows us to evaluate different options, consider alternative perspectives, and adjust our actions as needed to achieve our goals. These skills are at the foundation of cognitive flexibility, which plays a vital role in various stages of decision-making, within a dynamic and rapidly changing social context. However, the capacity to adjust our behavior appropriately based on context can be compromised in many brain disorders, including many neurodevelopmental and psychiatric diseases. As an example, Major Depressive Disorders as well as obsessive compulsive disturbances, autism and schizofrenia exhibit a marked reduction in cognitive flexibility leading to rigid thinking patterns and difficulties adapting to changing situations. Understanding the neurobiological foundations of these abilities could improve early diagnosis and pave the way for more effective interventions, enhancing patients’ quality of life and advancing our understanding of the fundamental workings of the brain.

The program will also includes a 2-hour poster session, giving young researchers the chance to present their work and engage with peers and experts in the field.

The SINS Committee for Education and Training

PROGRAM

09:30 Registration of Participants
10:00 Introduction of the congress and greetings from the authorities M. DiLuca
10:20 Modulation of L1 LNCRNAS at Striatal Circuits Shapes Flexible Behavioral Control R. Tonini
11:00 Discussion
11:10 Adaptive Decision-Making: from Cells to Circuits to Function D. Scheggia
11:50 Discussion
12:00 Lunch & Poster Session
14:00 How Expectations Shape the Perception of Aversive Events C. Buchel
14:40 Discussion
14:50 Cognitive Inflexibility in psychiatric diseases B. M. Dell'Osso
15:30 Discussion
15:40 Treatment of Autistic Symptoms in Rare Lysosomal Storage Disorders: from Bench to Bedside E. De Leonibus
16:20 Discussion
16:30 ECM test
16:50 Closing of the course

Speakers

Prof. Christian BuchelUniversity Medical Center Hamburg-Eppendorf, Germany
Dr. Elvira De LeonibusNational Research Council (CNR) and Telethon Institute of Genetics and Medicine (TIGEM), Italy
Prof. Bernardo Maria Dell’Osso – University of Milan, Italy
Dr. Diego ScheggiaUniversity of Milan, Italy
Dr. Raffaella ToniniItalian Institute of Technology (IIT), Italy

GENERAL INFORMATION

Venue

The workshop will take place at the prestigious Sala Napoleonica of Palazzo Greppi (Via Sant’Antonio, 10 – Milan)

Registration

All attendees are required to complete the online registration process via the Congress Management System

Registration fees

SINS Member FREE
NON-SINS members (aged 35 and under) 40 €
NON-SINS members (over 35) 80 €

The registration fee for non-sins members must be paid at the time of registration by:
Credit Card – direct online payment available during registration
Bank Transfer to LAAN S.a.s. – IBAN: IT60T0857511200000000706732

For any inquiries or further information regarding registration, please contact the SINS Secretariat via email at segreteria@sins.it or by phone at 0306340663.

ECM

The workshop is accredited for 100 participants by the LAAN Provider, granting 4 ECM credits.

The credits are valid for Medical Doctors specializing in Neurology, Child Neuropsychiatry, Psychiatry, and Clinical Pharmacology and Toxicology, as well as for Biologists and Psychologists.

To obtain the credits, participants must attend at least 90% of the scheduled training hours, achieve a minimum score of 75% on the learning assessment questionnaire, and complete the event evaluation questionnaire.

POSTER SESSION

C. Mucignat*¹, I. Pastore2, E. Bedin2, M. Beghetto2, C. Gallo2
¹ Department of Molecular Medicine, University of Padua, Padova | ² ULSS 6-S. Maria degli Angeli Hospital, Piove Di Sacco (PD)

A. Casile*1-3, B. Bonaldo2, A. Fallaha3, M. Bettarelli3, M.V. Micioni Di Bonaventura1, S. Gotti3-4, C. Cifani1
1 University of Camerino, Camerino (MC) | 2 University of Piemonte Orientale (UPO), Novara | 3 Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO) | 4 University of Turin, Torino

E. Manassero*1, G. Concina1, M.C.C. Caraig1, P. Sarasso2, A. Salatino2, R. Ricci2, B. Sacchetti1
1 Rita Levi-Montalcini Department of Neurosciences, University of Turin, Torino | 2 Department of Psychology, University of Turin, Torino

A. Lodi*1-2, L. Cifarelli1-2, A. Oberto1-2, V. Canicatti1, S. Muresu1, F. Dosio1, F. Luzzati1, I. Bertocchi1-2
¹ Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO) | 2 Department of Neuroscience Rita Levi Montalcini, University of Turin, Torino

F. Polverini*1, L. Curti2, M. Cerullo2, V. Scianaro2, A. Iurato La Rocca2, E. Gerace1, G. Mannaioni2, A. Masi2
¹ Department of Health Sciences (DSS), University of Florence, Firenze | ² Department of Neuroscience, Psychology, Pharmaceuticals and Child Health (NEUROFARBA), University of Florence, Firenze

M. Cerullo*1, F. Polverini2, L. Curti1, V. Scianaro1, A. Iurato La Rocca1, E. Gerace2, A. Masi1, G. Mannaioni1
¹ University of Florence (NEUROFARBA), Firenze | ² University of Florence (DSS), Firenze

A. Spinola*¹, M. Barzasi¹, C. Galizia², R. Gervasi¹, M. Di Luca¹, F. Gardoni¹
¹ Department of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, Milano | ² Interdisciplinary Institute for Neuroscience, CNRS, Univ. Bordeaux, IINS, UMR 5297, Bordeaux, France

M. Schiano Visconte*1, L. Pangrazzi1-2, L. Balasco3, Y. Bozzi1
¹ Centro Interdipartimentale Mente e Cervello, Rovereto (TN) | ² Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria | ³ Università Cattolica del Sacro Cuore, Bolzano

A. Longaretti*¹, D. Mangoni², V. Paget-blanc¹, A. Zlatanovic¹, A. Boender¹, Y. Pelloux¹, L. Nava¹, M. Veggi¹, P. Lau², G.G. Tartaglia², L. Graziani³, R. Sanges³, S. Gustincich², R. Tonini¹
¹ Fondazione Istituto Italiano di Tecnologia – Neuromodulation of Cortical and Subcortical Circuits Laboratory, Genova | ² Fondazione Istituto Italiano di Tecnologia – Non‑coding RNAs and RNA-based Therapeutics, Genova | ³ Area of Neuroscience, International School for Advanced Studies (SISSA), Trieste

A. Madhavan*1, L. Pangrazzi2-1, L. Dutton3-1, L. Balasco4, Y. Bozzi1
¹ Center for Mind/Brain Sciences, University of Trento, Rovereto (TN) | ² Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria | ³ University of Amsterdam, Amsterdam, Netherlands | ⁴ Università Cattolica del Sacro Cuore, Bolzano

L. Cifarelli*1-2, A. Oberto1-2, A. Lodi1-2, G. Trovato², S. Muresu², P. Zanella², F. Luzzati2-3, I. Bertocchi1-2
¹ Rita Levi-Montalcini Department of Neurosciences, University of Turin, Torino | 2 Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO) | ³ Department of Life Sciences and System Biology (DBIOS), University of Turin, Turin

S. Nasini*¹, S. Tidei¹, B. Barzon¹, A. Casile1-2, S. De Martin¹, A. Mattarei¹, M. Pappagallo³, P. L. Manfredi³, S. Comai¹
¹ University of Padua, Padova | ² University of Camerino, Camerino (MC) | ³ Relmada Therapeutics, Coral Gables, Florida, USA

R. Stringhi*¹, L. D’Andrea¹, F. La Greca¹, E. Zianni¹, L. Targa¹, C. Mosconi¹, L. Vandermeulen¹, M. Ascagni², M.C. Speciani³, V. Edefonti3-4, D. Scheggia¹, M. Di Luca¹, S. Pelucchi¹, E. Marcello¹
¹ Department of Pharmacological and Biomolecular Sciences “Rodolfo Paoletti”, University of Milan, Milano | ² Unitech NOLIMITS, University of Milan, Milano | ³ Department of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, University of Milan, Milano | ⁴ Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

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