Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding
Publication date: 08/04/2024
Authors: Hacisuleyman, E., Hale, C.R., Noble, N. et al.
Journal: Nature Neuroscience
Commentary: In this study, Hacisuleyman and colleagues uncover a novel mechanism by which neuronal activity controls local dendritic translation, a process critical for learning and memory. Using a proximity-based labeling platform coupled with omics approaches, the authors were able to detect activity-dependent changes in mRNA, translation, and protein levels at the synapse. Importantly, they discovered that upon depolarization, neurons did not produce new localized RNAs but rather recruit those already present in the dendritic compartment and enhance their translation through a mechanism that relies on the binding of eIF4G2 to specific sequences in the 5’UTR of mRNAs. This study offers new insights into how neurons control the synthesis of new proteins to sustain synaptic function and plasticity. Notably, activity-dependent molecular changes at synapses support many physiological brain functions, thus, understanding the underlying mechanisms is fundamental not only to deepen our knowledge of the brain but also in pathological contexts where these processes are impaired.
Commented by: Jessica Mingardi (25/02/2025)
DOI: https://doi.org/10.1038/s41593-024-01615-5
